TLX3 antibody (N-Term)

Catalog No. ABIN6991868

The Rabbit Polyclonal anti-TLX3 antibody is suitable to detect TLX3 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC (p) and IF.

Quick Overview for TLX3 antibody (N-Term) (ABIN6991868)

Target: TLX3 (T-Cell Leukemia Homeobox 3 (TLX3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLX3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-TLX3 Antibody

Binding Specificity: N-Term

Specificity: TLX3 antibody is predicted to not cross-react with other TLX proteins.

Purification: TLX3 Antibody is affinity chromatography purified via peptide column.

Immunogen: TLX3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX3. The immunogen is located within the first 50 amino acids of TLX3.

Isotype: IgG

Application Details

Application Notes: TLX3 antibody can be used for detection of TLX3 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TLX3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TLX3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TLX3

Target: TLX3 (T-Cell Leukemia Homeobox 3 (TLX3))

Alternative Name: TLX3

Background: TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).

Molecular Weight: Predicted: 32 kDa

Observed: 30 kDa

Gene ID: 30012

NCBI Accession: NP_066305

UniProt: O43711