AIMP2 antibody (AA 150-200)

Catalog No. ABIN6991920

This anti-AIMP2 antibody is a Rabbit Polyclonal antibody detecting AIMP2 in WB, ELISA, IF and IHC (p). Suitable for Human.

Quick Overview for AIMP2 antibody (AA 150-200) (ABIN6991920)

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AIMP2 Antibody

Binding Specificity: AA 150-200

Specificity: AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.

Purification: AIMP2 antibody is affinity chromatography purified via peptide column.

Immunogen: AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. The immunogen is located within amino acids 150 - 200 of AIMP2.

Isotype: IgG

Application Details

Application Notes: AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: AIMP2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: AIMP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for AIMP2

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Alternative Name: AIMP2

Background: AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease, accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).

Molecular Weight: Predicted: 35 kDa

Observed: 36 kDa

Gene ID: 7965

NCBI Accession: NP_006294

UniProt: Q13155