KDM1B antibody (N-Term)

Catalog No. ABIN6991923

Product Details anti-KDM1B Antibody

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Binding Specificity: AA 80-130, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM1B antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: KDM1B antibody is human, mouse and rat reactive. At least two isoforms of KDM1B are known to exist, this KDM1B antibody will detect both isoforms.

Purification: KDM1B antibody is affinity chromatography purified via peptide column.

Immunogen: KDM1B antibody was raised against a 17 amino acid peptide near the amino terminus of human KDM1B. The immunogen is located within amino acids 80 - 130 of KDM1B.

Isotype: IgG

Application Details

Application Notes: KDM1B antibody can be used for detection of KDM1B by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KDM1B antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KDM1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for KDM1B

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Alternative Name: KDM1B (KDM1B Products)

Synonyms: AOF1 antibody, C6orf193 antibody, LSD2 antibody, bA204B7.3 antibody, dJ298J15.2 antibody, 4632428N09Rik antibody, AI482520 antibody, Aof1 antibody, lysine demethylase 1B antibody, lysine-specific histone demethylase 1B antibody, lysine (K)-specific demethylase 1B antibody, KDM1B antibody, LOC577549 antibody, kdm1b antibody, Kdm1b antibody

Background: Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1). KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints, targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2). KDM1B has also been shown to play a role in the transcription elongation in several genes (3).

Molecular Weight: Predicted: 90 kDa

Observed: 90 kDa

Gene ID: 221656

NCBI Accession: NP_694587

UniProt: Q8NB78

Pathways: Warburg Effect