Dynamin 1-Like antibody (AA 530-580)

Catalog No. ABIN6991941

This anti-Dynamin 1-Like antibody is a Rabbit Polyclonal antibody detecting Dynamin 1-Like in WB, ELISA, IF and ICC. Suitable for Human and Mouse.

Quick Overview for Dynamin 1-Like antibody (AA 530-580) (ABIN6991941)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-Dynamin 1-Like Antibody

Binding Specificity: AA 530-580

Specificity: DNM1L antibody is human and mouse reactive. At least four isoforms of DNM1L are known to exist, this antibody will detect the two longest isoforms.

Purification: DNM1L antibody is affinity chromatography purified via peptide column.

Immunogen: DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L. The immunogen is located within amino acids 530 - 580 of DNM1L.

Isotype: IgG

Application Details

Application Notes: DNM1L antibody can be used for detection of DNM1L by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DNM1L antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DNM1L antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DNM1L

Background: The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1). DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2). Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3).

Molecular Weight: Predicted: 81 kDa

Observed: 80 kDa

Gene ID: 10059

NCBI Accession: NP_036192

UniProt: O00429