LAMTOR2 antibody (AA 40-90)

Catalog No. ABIN6991974

The Rabbit Polyclonal anti-LAMTOR2 antibody (ABIN6991974) specifically detects LAMTOR2 in WB, ELISA, IHC (p) and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LAMTOR2 antibody (AA 40-90) (ABIN6991974)

Target: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMTOR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-LAMTOR2 Antibody

Binding Specificity: AA 40-90

Specificity: LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist, this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.

Purification: LAMTOR2 antibody is affinity chromatography purified via peptide column.

Immunogen: LAMTOR2 antibody was raised against an 18 amino acid peptide near the center of human LAMTOR2. The immunogen is located within amino acids 40 - 90 of LAMTOR2.

Isotype: IgG

Application Details

Application Notes: LAMTOR2 antibody can be used for detection of LAMTOR2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LAMTOR2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LAMTOR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for LAMTOR2

Target: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Alternative Name: LAMTOR2

Background: The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2). This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4).

Molecular Weight: Predicted: 14 kDa

Observed: 16 kDa

Gene ID: 28956

NCBI Accession: NP_054736

UniProt: Q9Y2Q5

Pathways: PI3K-Akt Signaling