GJB2 antibody (AA 80-130)

Catalog No. ABIN6992084

The Rabbit Polyclonal anti-GJB2 antibody is suitable to detect GJB2 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for GJB2 antibody (AA 80-130) (ABIN6992084)

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GJB2 Antibody

Binding Specificity: AA 80-130

Specificity: GJB2 antibody is human specific.

Purification: GJB2 antibody is affinity chromatography purified via peptide column.

Immunogen: GJB2 antibody was raised against a 16 amino acid peptide near the center of human GJB2. The immunogen is located within amino acids 80 - 130 of GJB2.

Isotype: IgG

Application Details

Application Notes: GJB2 antibody can be used for detection of GJB2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GJB2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GJB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Alternative Name: GJB2

Background: The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1). Mutations in the GJB2 gene are thought to be responsible for as much as 35-45 % of congenital sensorineural hearing loss in some populations (2). Other mutations in this gene have also been linked to a wide array of skin diseases (3).

Molecular Weight: Predicted: 25 kDa

Observed: 26 kDa

Gene ID: 2706

NCBI Accession: NP_003995

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization