KLF17 antibody (C-Term)

Catalog No. ABIN6992086

This Rabbit Polyclonal antibody specifically detects KLF17 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KLF17 antibody (C-Term) (ABIN6992086)

Target: KLF17 (Kruppel-Like Factor 17 (KLF17))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KLF17 Antibody

Binding Specificity: C-Term

Specificity: KLF17 antibody is human, mouse and rat reactive. At least two isoforms of KLF17 are known to exist, this antibody will only detect the large isoform. KLF17 antibody is predicted to not cross-react with other KLF proteins.

Purification: KLF17 antibody is affinity chromatography purified via peptide column.

Immunogen: KLF17 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KLF17. The immunogen is located within the last 50 amino acids of KLF17.

Isotype: IgG

Application Details

Application Notes: KLF17 antibody can be used for detection of KLF17 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KLF17 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KLF17 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for KLF17

Target: KLF17 (Kruppel-Like Factor 17 (KLF17))

Alternative Name: KLF17

Background: KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1,2). KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3). Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3). Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4).

Molecular Weight: Predicted: 28, 39, 43 kDa

Observed: 38 kDa

Gene ID: 128209

NCBI Accession: NP_775755

UniProt: Q5JT82