KLF17 antibody (C-Term)

Catalog No. ABIN6992086

Product Details anti-KLF17 Antibody

Target: KLF17 (Kruppel-Like Factor 17 (KLF17))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: KLF17 antibody is human, mouse and rat reactive. At least two isoforms of KLF17 are known to exist, this antibody will only detect the large isoform. KLF17 antibody is predicted to not cross-react with other KLF proteins.

Purification: KLF17 antibody is affinity chromatography purified via peptide column.

Immunogen: KLF17 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KLF17. The immunogen is located within the last 50 amino acids of KLF17.

Isotype: IgG

Application Details

Application Notes: KLF17 antibody can be used for detection of KLF17 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KLF17 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KLF17 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for KLF17

Target: KLF17 (Kruppel-Like Factor 17 (KLF17))

Alternative Name: KLF17 (KLF17 Products)

Synonyms: zfp393 antibody, znf393 antibody, neptune antibody, rp4-675g8.1 antibody, ZNF393 antibody, Zfp393 antibody, 7420700M05Rik antibody, AA420409 antibody, AU043468 antibody, C85123 antibody, D4Ertd561e antibody, Gzf antibody, Kruppel-like factor 17 L homeolog antibody, Kruppel like factor 17 antibody, Kruppel-like factor 17 antibody, klf17.L antibody, KLF17 antibody, klf17 antibody, Klf17 antibody

Background: KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1,2). KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3). Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3). Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4).

Molecular Weight: Predicted: 28, 39, 43 kDa

Observed: 38 kDa

Gene ID: 128209

NCBI Accession: NP_775755

UniProt: Q5JT82