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Deltex Homolog 4 antibody (AA 230-280)

DTX4 Reactivity: Human, Mouse ELISA, WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6992091
  • Target See all Deltex Homolog 4 (DTX4) Antibodies
    Deltex Homolog 4 (DTX4) (Deltex Homolog 4 (Drosophila) (DTX4))
    Binding Specificity
    • 14
    • 7
    • 5
    • 3
    • 1
    AA 230-280
    Reactivity
    • 23
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Human, Mouse
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    This Deltex Homolog 4 antibody is un-conjugated
    Application
    • 18
    • 16
    • 7
    • 7
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist, this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.
    Purification
    DTX4 antibody is affinity chromatography purified via peptide column.
    Immunogen
    DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4. The immunogen is located within amino acids 230 - 280 of DTX4.
    Isotype
    IgG
    Top Product
    Discover our top product DTX4 Primary Antibody
  • Application Notes
    DTX4 antibody can be used for detection of DTX4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DTX4 antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    DTX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    Deltex Homolog 4 (DTX4) (Deltex Homolog 4 (Drosophila) (DTX4))
    Alternative Name
    DTX4 (DTX4 Products)
    Synonyms
    RNF155 antibody, AI449438 antibody, BC044798 antibody, D930042H13 antibody, zgc:163052 antibody, LRRGT00037 antibody, deltex E3 ubiquitin ligase 4 antibody, deltex 4, E3 ubiquitin ligase antibody, DTX4 antibody, Dtx4 antibody, dtx4 antibody
    Background
    The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).
    Molecular Weight
    Predicted: 68 kDa

    Observed: 68 kDa
    Gene ID
    23220
    NCBI Accession
    NP_055992
    UniProt
    Q9Y2E6
    Pathways
    Notch Signaling
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