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DUSP6 antibody

This Rabbit Polyclonal antibody specifically detects DUSP6 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN7235023

Quick Overview for DUSP6 antibody (ABIN7235023)

Target

See all DUSP6 Antibodies
DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity

  • 95
  • 58
  • 51
  • 2
  • 1
  • 1
Human, Mouse, Rat

Host

  • 82
  • 12
  • 2
  • 1
Rabbit

Clonality

  • 76
  • 21
Polyclonal

Conjugate

  • 45
  • 6
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This DUSP6 antibody is un-conjugated

Application

  • 63
  • 31
  • 19
  • 17
  • 11
  • 10
  • 9
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Characteristics

    Polyclonal Antibody

    Purification

    Affinity purification

    Immunogen

    Recombinant protein of human DUSP6

    Isotype

    IgG
  • Application Notes

    WB 1:500-1:2000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.4 mg/mL

    Buffer

    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

    Alternative Name

    MKP-3

    Background

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

    Molecular Weight

    27 kDa

    UniProt

    Q16828

    Pathways

    Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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