LDLR antibody

Catalog No. ABIN7249770

The Rabbit Polyclonal anti-LDLR antibody (ABIN7249770) specifically detects LDLR in IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LDLR antibody (ABIN7249770)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-LDLR Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to LDL Receptor

Isotype: IgG

Application Details

Application Notes: IHC 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR

Background: LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits,which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.

UniProt: P01130, P35951, P35952

Pathways: Hepatitis C, Lipid Metabolism