E-cadherin antibody
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- Target See all E-cadherin (CDH1) Antibodies
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
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Reactivity
- Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This E-cadherin antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Characteristics
- Monoclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Recombinant protein corresponding to MouseE-cadherin
- Clone
- EC125D
- Isotype
- IgG
- Top Product
- Discover our top product CDH1 Primary Antibody
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- Application Notes
- IHC 1:200-1:800
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.6 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- Alternative Name
- E-Cadherin (CDH1 Products)
- Background
- This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
- UniProt
- P09803, Q9R0T4
- Pathways
- WNT Signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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