PNKP antibody (AA 51-160)

Catalog No. ABIN700540

Product Details anti-PNKP Antibody

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Binding Specificity: AA 51-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNKP antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PNK1/PNKP

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PNKP

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Alternative Name: PNK1/PNKP (PNKP Products)

Synonyms: EIEE10 antibody, MCSZ antibody, PNK antibody, Tb06.28P18.320 antibody, 21.m03011 antibody, 1810009G08Rik antibody, polynucleotide kinase 3'-phosphatase antibody, hypothetical protein antibody, polynucleotide kinase 3'- phosphatase antibody, PNKP antibody, Pnkp antibody, Tc00.1047053507017.50 antibody, Tc00.1047053505807.190 antibody, Tb927.6.1580 antibody, BBOV_IV000690 antibody, CC1G_05202 antibody, PGTG_20262 antibody, PGTG_18987 antibody, pnkp.S antibody, pnkp antibody

Background:

Synonyms: Bunctional polynucleotide phosphatase/kinase, DEM 1, DEM1, DNA 5' kinase/3' phosphatase, PNK 1, PNK, PNK1, PNKP, Polynucleotide 5' hydroxyl kinase, Polynucleotide kinase 3 prime phosphatase, Polynucleotide kinase 3' phosphatase, Polynucleotide Kinase, PNKP_HUMAN.

Background: Mammalian PNK catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. It plays an important function in DNA repair following ionizing radiation or oxidative damage.PNK has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.

Gene ID: 11284

Pathways: DNA Damage Repair, Nucleotide Phosphorylation