POLD2 antibody

Catalog No. ABIN7253536

This Rabbit Polyclonal antibody specifically detects POLD2 in WB, ELISA and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for POLD2 antibody (ABIN7253536)

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-POLD2 Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human POLD2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.02 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for POLD2

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Alternative Name: POLD2

Background: This gene encodes the 50- kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 51 kDa

UniProt: P49005

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA