Septin 5 antibody

Catalog No. ABIN7256500

Product Details anti-Septin 5 Antibody

Target: Septin 5 (SEPT5)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Septin 5 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human 44079 (NP_002679.2).

Isotype: IgG

Application Details

Application Notes: IHC 1:100-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Septin 5

Target: Septin 5 (SEPT5)

Alternative Name: SEPT5 (SEPT5 Products)

Synonyms: sept5 antibody, fj37h04 antibody, zgc:73218 antibody, wu:fj37h04 antibody, SEPT5 antibody, Cdcrel-1 antibody, Cdcrel1 antibody, Pnutl1 antibody, 5-Sep antibody, CDCrel-1A antibody, CDCREL antibody, CDCREL-1 antibody, CDCREL1 antibody, H5 antibody, HCDCREL-1 antibody, PNUTL1 antibody, septin 5a antibody, septin 5 antibody, sept5a antibody, SEPT5 antibody, sept5 antibody, Sept5 antibody

Background: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB, platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Gene ID: 5413

UniProt: Q99719

Pathways: Synaptic Vesicle Exocytosis