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CASC5 antibody

CASC5 Reactivity: Human, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7256628
  • Target See all CASC5 Antibodies
    CASC5 (Cancer Susceptibility Candidate 5 (CASC5))
    Reactivity
    Human, Rat
    Host
    • 35
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CASC5 antibody is un-conjugated
    Application
    • 32
    • 15
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human CASC5 (NP_733468.3).
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000 IHC 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CASC5 (Cancer Susceptibility Candidate 5 (CASC5))
    Alternative Name
    CASC5 (CASC5 Products)
    Synonyms
    AF15Q14 antibody, CT29 antibody, D40 antibody, KNL1 antibody, PPP1R55 antibody, Spc7 antibody, hKNL-1 antibody, hSpc105 antibody, 2310043D08Rik antibody, 5730505K17Rik antibody, Rad51 antibody, kinetochore scaffold 1 antibody, Kinetochore null protein 1 antibody, KNL1 antibody, Knl1 antibody, knl-1 antibody
    Background
    The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11,15)(q23,q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
    Molecular Weight

    Observed_MW: 300 kDa

    Calculated_MW: 195 kDa/205 kDa/262 kDa/265 kDa

    Gene ID
    57082
    UniProt
    Q8NG31
    Pathways
    Maintenance of Protein Location, Autophagy
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