ZYX antibody

Catalog No. ABIN7260207

Product Details anti-ZYX Antibody

Target: ZYX (Zyxin (ZYX))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZYX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human ZYX (NP_001010972.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZYX

Target: ZYX (Zyxin (ZYX))

Alternative Name: ZYX (ZYX Products)

Synonyms: BcDNA:LD06023 antibody, CG32018 antibody, DLim-1 antibody, DmLIM-1 antibody, Dmel\\CG32018 antibody, Lim102EF antibody, ZYX102 antibody, Zyx102 antibody, Zyx102EF antibody, lim antibody, zyx102 antibody, zyxin antibody, zgc:171680 antibody, ZYX antibody, zyx antibody, MGC145270 antibody, ESP-2 antibody, HED-2 antibody, 9530098H06Rik antibody, R75157 antibody, Zyxin antibody, zyxin antibody, zyxin S homeolog antibody, zyx-1 antibody, Zyx antibody, zyx antibody, ZYX antibody, EDI_201420 antibody, zyx.S antibody

Background: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Molecular Weight:

Observed_MW: 78 kDa

Calculated_MW: 45 kDa/61 kDa

Gene ID: 7791

UniProt: Q15942