DPP4 antibody (PE)

Catalog No. ABIN7013983

The Rat Monoclonal anti-DPP4 antibody has been validated for FACS. It is suitable to detect DPP4 in samples from Mouse.

Quick Overview for DPP4 antibody (PE) (ABIN7013983)

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This DPP4 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: H194-112

Product Details anti-DPP4 Antibody (PE)

Purpose: Anti-Ms CD26 PE

Specificity: The rat monoclonal antibody H194-112 recognizes an extracellular epitope of CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: BALB/c thymocytes

Isotype: IgG2a kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for DPP4

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Alternative Name: CD26

Background: Dipeptidyl peptidase 4,CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.,DPP4, TP103, ADCP-2, ADABP

Gene ID: 13482

UniProt: P28843

Pathways: Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity