Mu Opioid Receptor 1 antibody (pSer375)

Catalog No. ABIN703210

This Rabbit Polyclonal antibody specifically detects Mu Opioid Receptor 1 in WB, IHC (p), IF (p) and IHC (fro). It exhibits reactivity toward Mouse and has been mentioned in 2+ publications.

Quick Overview for Mu Opioid Receptor 1 antibody (pSer375) (ABIN703210)

Target: Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mu Opioid Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Mu Opioid Receptor 1 Antibody

Binding Specificity: pSer375

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from rat mu Opioid Receptor around the phosphorylation site of Ser375

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Mu Opioid Receptor 1 antibody (ABIN703210)

Laureano, Dalle Molle, Alves, Luft, Desai, Ross, Silveira: "Intrauterine growth restriction modifies the hedonic response to sweet taste in newborn pups - Role of the accumbal μ-opioid receptors." in: Neuroscience, Vol. 322, pp. 500-8, (2016) (PubMed).

Brewer, Baran, Whitfield, Jensen, Clemens: "Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord." in: Frontiers in neural circuits, Vol. 8, pp. 62, (2014) (PubMed).

Target Details for Mu Opioid Receptor 1

Target: Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))

Alternative Name: mu Opioid Receptor

Background:

Synonyms: MORA, Oprm, Oprrm1, Mu-type opioid receptor, M-OR-1, MOR-1, Opioid receptor B, Oprm1, Ror-b

Background: This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Gene ID: 25601

UniProt: P33535

Pathways: cAMP Metabolic Process, Synaptic Membrane