Neuregulin 2 antibody (Extracellular)

Catalog No. ABIN7043355

Product Details anti-Neuregulin 2 Antibody

Target: Neuregulin 2 (NRG2)

Binding Specificity: AA 297-311, Extracellular

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: A Rabbit Polyclonal Antibody to Neuregulin-2

Specificity: Extracellular, N-terminus

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Mouse,human - identical

Characteristics: Anti-NRG2 (extracellular) Antibody (ABIN7043355, ABIN7044720 and ABIN7044721) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Neuregulin-2 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RDIRIKYGNGRKNSR, corresponding to amino acid residues 297-311 of rat Neuregulin-2

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200

Comment:

Negative Control: (ABIN7236030)

Blocking Peptide: (ABIN7236030)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for Neuregulin 2

Target: Neuregulin 2 (NRG2)

Alternative Name: NRG2 (NRG2 Products)

Background: Neuregulin-2, Pro-neuregulin-2 membrane-bound isoform, Pro-NRG2, Neural- and thymus-derived activator for ErbB kinases, NTAK,Neuregulins (NRGs) are a multi member protein family involved in cell to cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 which produce multiple isoforms through alternative splicing.NRGs are involved in several physiological processes including heart and peripheral nervous system development. They act in part by binding to the extracellular region of ErbB/HER transmembrane tyrosine kinases, leading to receptor dimerization and ultimately to the activation of a complex network of downstream signaling events1,2.NRG2 transcript levels markedly increase following birth, suggesting that NRG2 has important functions in the postnatal and adult brain. Several studies have also shown that NRG2 modulates glutamatergic transmission in GABAergic neurons and selectively affects GluN2B-containing NMDA receptors2,3.The region containing the NRG2 locus is associated with schizophrenia and other psychiatric disorders and genetically linked to ADHD in genome-wide scans2.

Alternative names: NRG2, Neuregulin-2, Pro-neuregulin-2 membrane-bound isoform, Pro-NRG2, Neural- and thymus-derived activator for ErbB kinases, NTAK

Gene ID: 432361

NCBI Accession: NM_013982

UniProt: O35569

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway