KCNK6 antibody (C-Term, Intracellular)

Catalog No. ABIN7886876

The Rabbit Polyclonal anti-KCNK6 antibody is suitable to detect KCNK6 in samples from Human. It has been validated for WB.

Quick Overview for KCNK6 antibody (C-Term, Intracellular) (ABIN7886876)

Target: KCNK6 (Potassium Channel Subfamily K Member 6 (KCNK6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNK6 Antibody

Binding Specificity: AA 295-313, C-Term, Intracellular

Purpose: A Rabbit Polyclonal Antibody to KCNK6 Channel

Cross-Reactivity: Human, Rat

Predicted Reactivity: Rat - 13,17 amino acid residues identical

Characteristics: Anti-KCNK6 Antibody (ABIN7043447 and ABIN7044950) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize KCNK6 from rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)ESHQQLSASSHTDYASIPR, corresponding to residues 295-313 of human KCNK6 

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236299)

Blocking Peptide: (ABIN7236299)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for KCNK6

Target: KCNK6 (Potassium Channel Subfamily K Member 6 (KCNK6))

Alternative Name: KCNK6

Background:

Synonyms: Potassium channel subfamily K member 6, TOSS, K2P6.1

Description: KCNK6 (also named Tandem of P domain of Weak Inward rectifier K+ channel 2, TWIK-2 or K2P6.1) is a member of the 2-pore (2P) domain K+ channel family that includes at least 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. The functional channel is believed to be a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH , mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.KCNK6 displays low single channel conductance of about 5pS and is partially activated by arachidonic acid and blocked by volatile anesthetics.KCNK6 expression is widespread, especially in the rat were it is expressed in brain, heart, kidney and liver. In humans KCNK6 expression is more restricted with expression in aorta, stomach, placenta and spleen while in mouse, KCNK6 expression has been detected only in liver.

Gene ID: 9424

NCBI Accession: NM_004823

UniProt: Q9Y257