STOML2 antibody (Intracellular)

Catalog No. ABIN7886510

This Rabbit Polyclonal antibody specifically detects STOML2 in WB. It exhibits reactivity toward Rat.

Quick Overview for STOML2 antibody (Intracellular) (ABIN7886510)

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STOML2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-STOML2 Antibody

Binding Specificity: AA 208-222, Intracellular

Purpose: A Rabbit Polyclonal Antibody to Stomatin-like Protein 2

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse,human - identical

Characteristics: Anti-STOML2/ Antibody (ABIN7043779, ABIN7044518 and ABIN7044519) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize Stomatin-like protein 2 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)EGTRESAINVAEGKK, corresponding to amino acid residues 208-222 of rat Stomatin-like protein 2

Isotype: IgG

Application Details

Application Notes:

WB: 1:400-1:800

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237288)

Blocking Peptide: (ABIN7237288)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for STOML2

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Alternative Name: STOML2

Background:

Synonyms: Paraprotein target 7, EPB72-like protein 2, Stomatin-like protein 2

Description: Stomatin-like protein 2 (STOML2, SLP-2) is a key protein on the mitochondrial inner membrane and a member of the stomatin superfamily. STOML2 is widely expressed in human tissues such as the brain, lung, and kidneys and interacts with prohibitin-1 and 2. It plays an important role in numerous physiological processes including organizing sphingolipid and cholesterol-rich lipid rafts, regulating ion channel conductance, and linking other integral membrane proteins to the peripheral cytoskeleton1,2.STOML2 shares a consensus stomatin signature sequence that defines the stomatin gene family. However, it lacks a NH2-terminal hydrophobic domain shared by other members3.Studies show that STOML2 expression is upregulated in various human cancer tissues including gastric cancer, endometrial adenocarcinoma, and breast cancer. The protein may play an important role in the incidence and development of tumor and it is suggested that SLP-2 is a potential oncogene. Knockdown of STOML2 protein significantly restrains the viability, migration, and invasion of hepatoma cell line1,2.

Gene ID: 298203

NCBI Accession: NM_013442

UniProt: Q4FZT0

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection