TAAR1 antibody (C-Term, Intracellular)

Catalog No. ABIN7887179

This Rabbit Polyclonal antibody specifically detects TAAR1 in WB. It exhibits reactivity toward Rat.

Quick Overview for TAAR1 antibody (C-Term, Intracellular) (ABIN7887179)

Target: TAAR1 (Trace Amine Associated Receptor 1 (TAAR1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAAR1 Antibody

Binding Specificity: AA 313-325, C-Term, Intracellular

Purpose: A Rabbit Polyclonal Antibody to Trace Amine Receptor 1

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse,human - 12,13 amino acid residues identical

Characteristics: Anti-Trace Amine Receptor 1 (TAAR1) Antibody is directed against an epitope of the rat Trace amine-associated receptor 1. Anti-Trace Amine Receptor 1 (TAAR1) Antibody (ABIN7043812, ABIN7045324 and ABIN7045325) can be used in western blot analysis. It has been designed to recognize TAAR1 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)KMVLFGKIFQKDS, corresponding to amino acid residues 313-325 of rat TAAR1

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237397)

Blocking Peptide: (ABIN7237397)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for TAAR1

Target: TAAR1 (Trace Amine Associated Receptor 1 (TAAR1))

Alternative Name: TAAR1

Background:

Synonyms: Trace amine-associated receptor 1, TaR-1, TA1, TRAR1

Description: Trace amines are compounds, such as p-tyramine and tryptamine, found in the body in trace amounts. These substances were believed to mainly modulate aminergic pathways. However, they were found to activate Trace amino associated receptors (TAARs), members of the G-protein coupled receptor (GPCRs) superfamily1.Trace amine receptor 1 (TAAR-1) is part of the Rhodopsin family of GPCRs. Five other putative genes are thought to encode TAAR receptors. This receptor has a seven transmembrane domain with short extracellular N- and intracellular C- terminal domains.TAAR-1 couples Gs, thus leading to an increase in intracellular cAMP levels. Its signaling might be enhanced by monoamine transporters, and activation of TAAR-1 may also affect monoamine transport function. The receptor also inhibits PKA and PKC mediated dopamine uptake and PKC mediated dopamine efflux2. It is also possible that it forms heterodimers with dopamine receptors, thus influencing dopamine transmission3.In humans, this receptor is mainly expressed in the stomach but is also detected in the lungs, small intestine and many cerebral and cerebellar tissues including the amygdala, hypothalamus and others4.In experiments conducted in mice it was shown that TAAR-1 knockout mice display increased stimulation effects of d-amphetamine, greater levels of extracellular monoamine and hyperactivity. These effects are related to clinical conditions such as ADHD, psychosis and other psychiatric problems5. Additional studies on TAAR family receptors may be helpful in finding cutting edge treatment.

Gene ID: 113914

NCBI Accession: NM_138327

UniProt: Q923Y9