Recombinant Endoglin antibody

Catalog No. ABIN7072352

The Rat Monoclonal anti-Endoglin antibody is suitable to detect Endoglin in samples from Mouse. It has been validated for WB, FACS, IHC and IP.

Quick Overview for Recombinant Endoglin antibody (ABIN7072352)

Target: Endoglin (ENG)

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: MJ7-18

Product Details anti-Endoglin Antibody

Purpose: Anti-CD105 [MJ7/18], Rat IgG2a, kappa

Specificity: MJ7/18 binds specifically to mouse CD105. CD105 is a homodimer expressed by vascular endothelial cells. CD105 functions in adhesion and embryonic angiogenesis. CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.

Isotype: IgG2a kappa

Application Details

Application Notes: MJ7/18 can be used for FC, WB, IP and IHC (Baluk P, et al. 2003. Am. J. Pathol. 163:1801).

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105

Background: Endoglin, Cell surface MJ7/18 antigen

UniProt: Q63961