Recombinant IL-5 antibody

Catalog No. ABIN7072522

This Rabbit Chimeric antibody specifically detects IL-5 in ELISA and Neut. It exhibits reactivity toward Human.

Quick Overview for Recombinant IL-5 antibody (ABIN7072522)

Target: IL-5 (IL5) (Interleukin 5 (IL5))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This IL-5 antibody is un-conjugated

Application: ELISA, Neutralization (Neut)

Clone: 2E3

Product Details anti-IL-5 Antibody

Purpose: Anti-IL-5 [2E3], Rabbit IgG, kappa

Specificity: This antibody is specific for human rIL-5, and does not cross-react with human rIL-1α, rIL-lβ, rIL-4, rIL-8, rM-CSF, or rTGF-α.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunising CAF1 mice with human recombinant IL-5.

Isotype: IgG kappa

Application Details

Application Notes: This antibody has been show to inhibit the binding of human rIL-5 to the alpha chain of the IL-5 receptor (Ames et al, 1995). This antibody inhibits the proliferation of murine B13 cells in response to human IL-5 (Ames et al, 1995).Neutralising antibodies against IL-5 represent a potential therapeutic strategy for the treatment of eosinophilia. The specificity of this antibody for human IL-5 has been confirmed in ELISA analysis (Ames et al, 1995).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for IL-5

Target: IL-5 (IL5) (Interleukin 5 (IL5))

Alternative Name: IL-5

Background: Interleukin 5, IL5, IL 5, Eosinophil differentiation factor

UniProt: C9JQP9

Pathways: JAK-STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Feeding Behaviour