alpha Actinin antibody

Catalog No. ABIN7073023

The Rabbit Polyclonal anti-alpha Actinin antibody (ABIN7073023) specifically detects alpha Actinin in WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for alpha Actinin antibody (ABIN7073023)

Target: alpha Actinin (ACTN) (alpha-Actinin Skeletal Muscle (ACTN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha Actinin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-alpha Actinin Antibody

Cross-Reactivity: Mouse, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Human ACTN1

Application Details

Application Notes: WB (H,M,R) 1:500-1:1000, IHC/IF (M,R) 1:500-1:1000/1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for alpha Actinin

Target: alpha Actinin (ACTN) (alpha-Actinin Skeletal Muscle (ACTN))

Alternative Name: alpha Actinin

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

Molecular Weight: 103 kDa

Gene ID: 109711

NCBI Accession: NP_001093

UniProt: P12814

Pathways: Cell-Cell Junction Organization, Negative Regulation of Transporter Activity