RNF7 antibody

Catalog No. ABIN7075471

Product Details anti-RNF7 Antibody

Target: RNF7 (Ring Finger Protein 7 (RNF7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF7 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse RNF7

Application Details

Application Notes: IHC/IF (H,M,R) 1:500-1:2000/1:500-1:3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for RNF7

Target: RNF7 (Ring Finger Protein 7 (RNF7))

Alternative Name: RNF7 (RNF7 Products)

Background: The RNF7 is probable a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

Gene ID: 19823

NCBI Accession: NP_001298064

UniProt: Q9WTZ1

Pathways: Positive Regulation of Endopeptidase Activity