NGFR antibody (iFluor™647)

Catalog No. ABIN7077081

This Mouse Monoclonal antibody specifically detects NGFR in FACS. It exhibits reactivity toward Human.

Quick Overview for NGFR antibody (iFluor™647) (ABIN7077081)

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NGFR antibody is conjugated to iFluor™647

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: ME20-4

Product Details anti-NGFR Antibody (iFluor™647)

Purpose: CD271 iFluor647 Antibody

Characteristics: The clone ME20.4, a mouse monoclonal antibody selectively binds with a ~75 kD type I transmembrane protein known as CD271. It is also known as the nerve growth factor receptor (NGFR) and a member of the tumor necrosis factor receptor (TNFR) superfamily.  Various cell types express CD271 including neuronal axons, Schwann cells, mesenchymal stem cells, epithelial cells, etc.  Increased levels of CD271 were observed in brain metastatic melanoma cells and in lung-metastasizing melanoma cells. It is a transmembrane signaling receptor involved in negative cell cycle regulation and is specific for neural crest origin.

Purification: Purified

Purity: >95 %

Immunogen: WM245 melanoma cells

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Alternative Name: CD271

Gene ID: 4804

UniProt: P08138

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding