CDKN2B antibody

Catalog No. ABIN706166

The Rabbit Polyclonal anti-CDKN2B antibody is suitable to detect CDKN2B in samples from Human, Mouse, Rat, Dog, Cow and Chicken. It has been validated for WB, IHC (p) and IF (p).

Quick Overview for CDKN2B antibody (ABIN706166)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reactivity: Human, Mouse, Rat, Dog, Cow, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CDKN2B Antibody

Cross-Reactivity: Rat (Rattus), Chicken, Dog (Canine), Cow (Bovine)

Purification: purified by Protein A and peptide affinity chromatography

Immunogen: KLH conjugated synthetic peptide derived from human CDKN2B

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C for 12 months

Expiry Date: 12 months

Target Details for CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Alternative Name: CDKN2B

Background: P15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers.

Molecular Weight: 15kDa

Gene ID: 1030

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases