Recombinant Caldesmon antibody

Catalog No. ABIN7090803

This Rabbit Monoclonal antibody specifically detects Caldesmon in WB, IF, IHC (p), ICC and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for Recombinant Caldesmon antibody (ABIN7090803)

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Caldesmon antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Caldesmon Antibody

Purpose: Caldesmon Recombinant Antibody

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Caldesmon

Isotype: IgG

Application Details

Application Notes: WB(1:2000-20000), IHC-P(1:200-1000), IHC-F(1:200-1000), IF(1:200-1000), ICC/IF(1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Caldesmon

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Alternative Name: Caldesmon

Background:

Synonyms: CAD, CALD 1, CALD1, Caldesmon 1, Caldesmon 1 Isoform 1, Caldesmon 1 Isoform 2, aldesmon 1 Isoform 3, Caldesmon 1 Isoform 4, Caldesmon 1 Isoform 5, Caldesmon1, CDM, H CAD, HCAD, L CAD, LCAD, MGC21352, NAG22, Caldesmon-Pan, CALD1_HUMAN.

Background: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jul 2008].

Gene ID: 800

UniProt: Q05682

Pathways: Myometrial Relaxation and Contraction