DNMT3A antibody

Catalog No. ABIN7091044

The Mouse Monoclonal anti-DNMT3A antibody has been validated for WB. It is suitable to detect DNMT3A in samples from Human.

Quick Overview for DNMT3A antibody (ABIN7091044)

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DNMT3A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: G8L1

Product Details anti-DNMT3A Antibody

Predicted Reactivity: Human

Immunogen: Recombinant human Dnmt3a.

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DNMT3A

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Alternative Name: Dnmt3a

Background:

Synonyms: DNA (cytosine 5 ) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaI, DNA MTase HsaIIIA, DNMT 3a, DNMT, DNMT3A2, M HsaIIIA, M.HsaIIIA, MCMT, Methyl CpG binding domain protein 3a.

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

Gene ID: 1788

UniProt: Q9Y6K1