FGFR2 antibody

Catalog No. ABIN7091110

The Rabbit Monoclonal anti-FGFR2 antibody has been validated for IHC (p). It is suitable to detect FGFR2 in samples from Human.

Quick Overview for FGFR2 antibody (ABIN7091110)

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FGFR2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: E2F12

Product Details anti-FGFR2 Antibody

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FGFR2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FGFR2

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Alternative Name: FGFR2

Background:

Synonyms: KGFR, KSAM, Bacteria expressed kinase, BEK, BEK fibroblast growth factor receptor, BFR 1, BFR1, CD 332, CD332, CD332 antigen, CEK 3, CEK3, CFD 1, CFD1, Craniofacial dysostosis 1, Crouzon syndrome, ECT 1, ECT 1, ECT1, FGF receptor, FGFR 2, FGFR-2, FGFR2_HUMAN, Fibroblast growth factor receptor 2, Hydroxyaryl protein kinase, Hydroxyaryl protein kinase, Jackson Weiss syndrome, JWS, JWS antibody K SAM, K sam protein, K sam protein, K-sam , Keratinocyte growth factor receptor 2, Keratinocyte growth factor receptor, Pfeiffer syndrome, Protein tyrosine kinase receptor like 14, TK14, TK25, Tyrosylprotein kinase, Tyrosylprotein kinase.

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Gene ID: 2263

UniProt: P21802

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding