IDO1 antibody

Catalog No. ABIN7091242

The Rabbit Monoclonal anti-IDO1 antibody has been validated for IHC (p). It is suitable to detect IDO1 in samples from Human.

Quick Overview for IDO1 antibody (ABIN7091242)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This IDO1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ID2C1

Product Details anti-IDO1 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IDO1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Alternative Name: IDO1

Background:

Synonyms: Indoleamine 2, 3-dioxygenase , 3-dioxygenase, I23O1_HUMAN, IDO 1, IDO, IDO-1, INDO, indolamine 2,3 dioxygenase, Indole 2 3 dioxygenase, indoleamine 2 3 dioxygenase 1, indoleamine 2 3 dioxygenase, Indoleamine 2,3-dioxygenase 1, Indoleamine pyrrole 2 3 dioxygenase, Indoleamine-pyrrole 2, indoleamine-pyrrole 2,3 dioxygenase.

Background: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Gene ID: 3620

UniProt: P14902

Pathways: Activated T Cell Proliferation