ITGA4 antibody (Biotin)
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- Target See all ITGA4 Antibodies
- ITGA4 (Integrin alpha 4 (ITGA4))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ITGA4 antibody is conjugated to Biotin
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Integrin alpha 4
- Isotype
- IgG
- Top Product
- Discover our top product ITGA4 Primary Antibody
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- Application Notes
- WB 1:300-5000
- Restrictions
- For Research Use only
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- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- ITGA4 (Integrin alpha 4 (ITGA4))
- Alternative Name
- Integrin alpha 4 (ITGA4 Products)
- Synonyms
- CD49D antibody, IA4 antibody, LOC100219853 antibody, integrin subunit alpha 4 antibody, integrin alpha 4 antibody, integrin subunit alpha 4 S homeolog antibody, ITGA4 antibody, Itga4 antibody, itga4.S antibody
- Background
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Synonyms: Alpha 4 subunit of VLA 4 receptor,ITG-_4: Antigen CD49D, CD 49d , CD49d, CD49d antigen, CDw49d, IA4, Integrin alpha IV, ITGA 4, ITGA4, LPAM23, MGC90518, Very Late Activation Antigen 4, Very Late Activation Protein 4 Receptor Alpha 4 Subunit, VLA 4, VLA4, integrin alpha-4, ITA4_HUMAN,
Background: Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.
- Gene ID
- 3676
- UniProt
- P13612
- Pathways
- Integrin Complex
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