Lamin A/C antibody (AA 1-100)

Catalog No. ABIN7091321

This anti-Lamin A/C antibody is a Mouse Monoclonal antibody detecting Lamin A/C in WB. Suitable for Human and Rat.

Quick Overview for Lamin A/C antibody (AA 1-100) (ABIN7091321)

Target: Lamin A/C (LMNA)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3E1

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 1-100

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: Recombinant human lamin A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Background:

Synonyms: Lamin A + Lamin C, Lamin A + C, LMN1, 70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LAMIN A, lamin A/C, LAMIN C, LDP1, LFP, LGMD1B, LMN 1, LMN A, LMN C, LMNA, LMNC, NY REN 32 antigen, PRO1, LMNA_HUMAN, Prelamin-A/C, Renal carcinoma antigen NY-REN-32.

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus