Patched 1 antibody (AA 1-100)

Catalog No. ABIN7091516

This anti-Patched 1 antibody is a Rabbit Polyclonal antibody detecting Patched 1 in WB and ELISA. Suitable for Mouse and Rat.

Quick Overview for Patched 1 antibody (AA 1-100) (ABIN7091516)

Target: Patched 1 (PTCH1)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Patched 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Patched 1 Antibody

Binding Specificity: AA 1-100

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Patched

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Patched 1

Target: Patched 1 (PTCH1)

Alternative Name: Patched

Background:

Synonyms: Protein patched homolog 1, PTCH, PTC1, A230106A15Rik, BCNS, FLJ26746, FLJ42602, Holoprosencephaly 7, HPE7, mes, NBCCS, OTTHUMP00000021709, OTTHUMP00000021710, Patched, Patched (Drosophila) homolog, Patched 1, Patched homolog (Drosophila), Patched homolog 1 (Drosophila), Patched homolog 1, Patched protein homolog 1, PTC, PTC1, PTCH, PTCH protein +12b, PTCH protein +4', PTCH protein -10, PTCH protein, PTCH1, PTCH1 protein, PTCH11, Ptch2, , Patched / PTCH, PTC1_HUMAN.

Background: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Gene ID: 5727

UniProt: Q13635

Pathways: Hedgehog Signaling, Carbohydrate Homeostasis, Tube Formation