R-Spondin 3 antibody (AA 22-100) (HRP)

Catalog No. ABIN7091622

This Rabbit Polyclonal antibody specifically detects R-Spondin 3 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for R-Spondin 3 antibody (AA 22-100) (HRP) (ABIN7091622)

Target: R-Spondin 3 (RSPO3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This R-Spondin 3 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA

Product Details anti-R-Spondin 3 Antibody (HRP)

Binding Specificity: AA 22-100

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse,Cat,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RSPO3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Alternative Name: RSPO3

Background:

Synonyms: CRISTIN1, hPWTSR, hRspo3, Protein with TSP type-1 repeat, PWTSR, R-spondin 3 homolog, R-spondin-3 [Precursor], R-spondin-3, Roof plate specific spondin-3, Roof plate-specific spondin-3, RSPO3_HUMAN, Thrombospondin type I domain containing 2, Thrombospondin type-1 domain-containing protein 2, THSD2.

Background: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Gene ID: 84870

UniProt: Q9BXY4