Cyclin D1 antibody (AA 65-245)

Catalog No. ABIN7113141

This anti-Cyclin D1 antibody is a Mouse Monoclonal antibody detecting Cyclin D1 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for Cyclin D1 antibody (AA 65-245) (ABIN7113141)

Target: Cyclin D1 (CCND1)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin D1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 8E8

Product Details anti-Cyclin D1 Antibody

Binding Specificity: AA 65-245

Purpose: CCND1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 65-245aa

Immunogen: cyclin D1

Isotype: IgG2a

Application Details

Application Notes: WB: 1:2000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Cyclin D1

Target: Cyclin D1 (CCND1)

Alternative Name: CCND1

Background:

Synonyms: G1/S-specific cyclin-D1|B-cell lymphoma 1 protein (BCL-1)|BCL-1 oncogene|PRAD1 oncogene|CCND1|BCL1|PRAD1

Background: CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

Molecular Weight: 36 kDa

Gene ID: 595

UniProt: P24385

Pathways: PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling