DCUN1D1 antibody

Catalog No. ABIN7113384

The Rabbit Polyclonal anti-DCUN1D1 antibody (ABIN7113384) specifically detects DCUN1D1 in ELISA, WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for DCUN1D1 antibody (ABIN7113384)

Target: DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCUN1D1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-DCUN1D1 Antibody

Purpose: DCUN1D1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DCN1, defective in cullin neddylation 1, domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DCUN1D1

Target: DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))

Alternative Name: DCUN1D1

Background:

Synonyms: DCN1-like protein 1 (DCNL1)|DCUN1 domain-containing protein 1|Defective in cullin neddylation protein 1-like protein 1|Squamous cell carcinoma-related oncogene|DCUN1D1|DCN1|DCUN1L1|RP42|SCCRO

Background: Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8(UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates(PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression(By similarity).

Molecular Weight: 28 kDa

Gene ID: 54165

UniProt: Q96GG9