DENND1A antibody

Catalog No. ABIN7113415

This Rabbit Polyclonal antibody specifically detects DENND1A in ELISA, WB and IF. It exhibits reactivity toward Human.

Quick Overview for DENND1A antibody (ABIN7113415)

Target: DENND1A (DENN/MADD Domain Containing 1A (DENND1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DENND1A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DENND1A Antibody

Purpose: DENND1A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DENN/MADD domain containing 1A

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DENND1A

Target: DENND1A (DENN/MADD Domain Containing 1A (DENND1A))

Alternative Name: DENND1A

Background:

Synonyms: DENN domain-containing protein 1A|Connecdenn 1 (Connecdenn)|Protein FAM31A|DENND1A|FAM31A|KIAA1608

Background: Guanine nucleotide exchange factor(GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes(PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates(PtdInsPs), with some preference for PtdIns(3)P(By similarity).

Molecular Weight: 111 kDa, 64 kDa

Gene ID: 57706

UniProt: Q8TEH3