ERCC3 antibody

Catalog No. ABIN7113553

This Rabbit Polyclonal antibody specifically detects ERCC3 in WB, ELISA and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for ERCC3 antibody (ABIN7113553)

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ERCC3 Antibody

Purpose: ERCC3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ERCC3

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Alternative Name: ERCC3

Background:

Synonyms: General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB)|Basic transcription factor 2 89 kDa subunit (BTF2 p89)|DNA excision repair protein ERCC-3|DNA repair protein complementing XP-B cells|TFIIH basal transcription factor complex 89 kDa subunit (TFIIH 89 kDa subunit, TFIIH p89)|Xeroderma pigmentosum group B-complementing protein|ERCC3|XPB|XPBC

Background: This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants.

Molecular Weight: 80 kDa

Gene ID: 2071

UniProt: P19447

Pathways: DNA Damage Repair