EIF3L antibody

Catalog No. ABIN7113957

The Rabbit Polyclonal anti-EIF3L antibody (ABIN7113957) specifically detects EIF3L in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for EIF3L antibody (ABIN7113957)

Target: EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-EIF3L Antibody

Purpose: EIF3L antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: eukaryotic translation initiation factor 3, subunit L

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for EIF3L

Target: EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))

Alternative Name: EIF3L

Background:

Synonyms: Eukaryotic translation initiation factor 3 subunit L (eIF3l)|Eukaryotic translation initiation factor 3 subunit 6-interacting protein|Eukaryotic translation initiation factor 3 subunit E-interacting protein|EIF3L|EIF3EIP|EIF3S6IP

Background: Component of the eukaryotic translation initiation factor 3(eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex(43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2(PubMed:18056426).

Molecular Weight: 67 kDa

Gene ID: 51386

UniProt: Q9Y262

Pathways: Ribonucleoprotein Complex Subunit Organization