ERCC6 antibody

Catalog No. ABIN7113989

The Rabbit Polyclonal anti-ERCC6 antibody has been validated for WB and ELISA. It is suitable to detect ERCC6 in samples from Human, Rat and Mouse.

Quick Overview for ERCC6 antibody (ABIN7113989)

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ERCC6 Antibody

Purpose: ERCC6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: excision repair cross-complementing rodent repair deficiency, complementation group 6

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ERCC6

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Alternative Name: ERCC6

Background:

Synonyms: DNA excision repair protein ERCC-6|ATP-dependent helicase ERCC6|Cockayne syndrome protein CSB|ERCC6|CSB

Background: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex(DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.

Molecular Weight: 150 kDa

Gene ID: 2074

UniProt: Q03468

Pathways: DNA Damage Repair, Chromatin Binding