GOT1 antibody
Quick Overview for GOT1 antibody (ABIN7114620)
Target
See all GOT1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Purification
- Protein A+G purification
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Purity
- ≥95 % as determined by SDS-PAGE
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Immunogen
- glutamic-oxaloacetic transaminase 1, soluble(aspartate aminotransferase 1)
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Isotype
- IgG2a
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Application Notes
- WB: 1:500-1:2000, IHC: 1:20-1:200
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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Expiry Date
- 12 months
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- GOT1 (Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1) (GOT1))
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Alternative Name
- GOT1
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Background
- Synonyms:AATC, CAT, GIG18, GOT1, Transaminase A Background:Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase(3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
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Molecular Weight
- 43 kDa
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Gene ID
- 2805
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UniProt
- P17174
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Pathways
- Hepatitis C, Monocarboxylic Acid Catabolic Process, Methionine Biosynthetic Process
Target
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