IDO1 antibody (AA 1-403)

Catalog No. ABIN7115217

This anti-IDO1 antibody is a Rabbit Polyclonal antibody detecting IDO1 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for IDO1 antibody (AA 1-403) (ABIN7115217)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-IDO1 Antibody

Binding Specificity: AA 1-403

Purpose: IDO1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-403aa,full length

Immunogen: indoleamine 2,3-dioxygenase 1

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:4000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Alternative Name: IDO1

Background:

Synonyms: Indoleamine 2,3-dioxygenase 1 (IDO-1)|Indoleamine-pyrrole 2,3-dioxygenase|IDO1|IDO|INDO

Background: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway(PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses(PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells(PubMed:25691885). Acts as a suppressor of anti-tumor immunity(PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immune rejection(PubMed:25691885).

Molecular Weight: 42 kDa

Gene ID: 3620

UniProt: P14902

Pathways: Activated T Cell Proliferation