MCL-1 antibody

Catalog No. ABIN7115221

This Mouse Monoclonal antibody specifically detects MCL-1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for MCL-1 antibody (ABIN7115221)

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MCL-1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 6F10

Product Details anti-MCL-1 Antibody

Purpose: MCL1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: myeloid cell leukemia sequence 1(BCL2-related)

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:10000, IHC: 1:200-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Alternative Name: MCL1

Background:

Synonyms: Induced myeloid leukemia cell differentiation protein Mcl-1|Bcl-2-like protein 3 (Bcl2-L-3)|Bcl-2-related protein EAT/mcl1|mcl1/EAT|MCL1|BCL2L3

Background: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Molecular Weight: 37 kDa

Gene ID: 4170

UniProt: Q07820

Pathways: MAPK Signaling