IVNS1ABP antibody

Catalog No. ABIN7115224

This Rabbit Polyclonal antibody specifically detects IVNS1ABP in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IVNS1ABP antibody (ABIN7115224)

Target: IVNS1ABP (Influenza Virus NS1A Binding Protein (IVNS1ABP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IVNS1ABP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-IVNS1ABP Antibody

Purpose: IVNS1ABP antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: influenza virus NS1A binding protein

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IVNS1ABP

Target: IVNS1ABP (Influenza Virus NS1A Binding Protein (IVNS1ABP))

Alternative Name: IVNS1ABP

Target Type: Influenza Protein

Background:

Synonyms: Influenza virus NS1A-binding protein (NS1-BP, NS1-binding protein)|Aryl hydrocarbon receptor-associated protein 3|Kelch-like protein 39|IVNS1ABP|ARA3|FLARA3|KIAA0850|KLHL39|NS1|NS1BP

Background: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization, Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines(By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing, may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.

Molecular Weight: 70 kDa

Gene ID: 10625

UniProt: Q9Y6Y0

Pathways: Negative Regulation of intrinsic apoptotic Signaling