IFT57 antibody
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- Target See all IFT57 Antibodies
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IFT57 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- intraflagellar transport 57 homolog(Chlamydomonas)
- Isotype
- IgG
- Top Product
- Discover our top product IFT57 Primary Antibody
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- Application Notes
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
- Alternative Name
- IFT57 (IFT57 Products)
- Background
- Synonyms:DERP8, ESRRBL1, HIPPI Background:Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway(By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8(CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.
- Molecular Weight
- 49kd
- Gene ID
- 55081
- UniProt
- Q9NWB7
- Pathways
- Hedgehog Signaling, Positive Regulation of Endopeptidase Activity
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