LINGO1 antibody

Catalog No. ABIN7115801

The Rabbit Polyclonal anti-LINGO1 antibody has been validated for WB and ELISA. It is suitable to detect LINGO1 in samples from Human, Mouse and Rat.

Quick Overview for LINGO1 antibody (ABIN7115801)

Target: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LINGO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LINGO1 Antibody

Purpose: LINGO1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: leucine rich repeat and Ig domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for LINGO1

Target: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Alternative Name: LINGO1

Background:

Synonyms: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1|Leucine-rich repeat and immunoglobulin domain-containing protein 1|Leucine-rich repeat neuronal protein 1|Leucine-rich repeat neuronal protein 6A|LINGO1|LERN1|LRRN6A

Background: Functional component of the Nogo receptor signaling complex(RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors(PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination(PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development(By similarity).

Molecular Weight: 83 kDa

Gene ID: 84894

UniProt: Q96FE5