MORF4L1 antibody

Catalog No. ABIN7116503

The Rabbit Polyclonal anti-MORF4L1 antibody has been validated for WB, ELISA, IHC and IP. It is suitable to detect MORF4L1 in samples from Human, Mouse and Rat.

Quick Overview for MORF4L1 antibody (ABIN7116503)

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MORF4L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-MORF4L1 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: mortality factor 4 like 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for MORF4L1

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Alternative Name: MORF4L1

Background: Synonyms:MRG15 Background:Component of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair(HRR) and resistance to mitomycin C(MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Molecular Weight: 35-37 kDa

Gene ID: 10933

UniProt: Q9UBU8

Pathways: Chromatin Binding