NGEF antibody
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- Target See all NGEF Antibodies
- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NGEF antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- neuronal guanine nucleotide exchange factor
- Isotype
- IgG
- Top Product
- Discover our top product NGEF Primary Antibody
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- Application Notes
- WB: 1:500-1:1000, IP: 1:500-1:1000, IHC: 1:50-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
- Alternative Name
- NGEF (NGEF Products)
- Background
- Synonyms: Background:Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).
- Molecular Weight
- 75 kDa
- Gene ID
- 25791
- UniProt
- Q8N5V2
- Pathways
- Neurotrophin Signaling Pathway
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